Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice

Nobuaki Egashira, Kazuhide Hayakawa, Kenichi Mishima, Hitomi Kimura, Katsunori Iwasaki, Michihiro Fujiwara

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77 Citations (Scopus)


In the present study, we examined the neuroprotective effect of γ-glutamylethylamide (theanine) on the ischemic brain damage in a middle cerebral artery occlusion model in mice. Theanine was injected i.p. 3 h after the occlusion or immediately before and 3 h after the occlusion. Theanine (1 mg/kg) significantly decreased the size of the cerebral infarcts 1 day after the occlusion. In contrast, theanine did not affect the cerebral blood flow, brain temperature and physiological variables (pH, pCO2, pO2 and hematocrit) in this model. These results suggest that theanine directly provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Jun 3 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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