Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation

Takato Morioka; Shunji Nishio; Kei Hisada; Hiroshi Shigeto; Tomoya Yamamoto; Kiyotaka Fujii; Masashi Fukui

doi:10.1007/PL00011956

Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation

Takato Morioka, Shunji Nishio, Kei Hisada, Hiroshi Shigeto, Tomoya Yamamoto, Kiyotaka Fujii, Masashi Fukui

Division of Medical Technology

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Magnetoencephalographic (MEG) activities were recorded in five patients with cerebral arteriovenous malformation (AVM) who presented with epilepsy and no clinical history of intracranial hemorrhage, using a 37-channel DC superconducting quantum interference device (SQUID) system. While scalp-recorded electroencephalograms (EEG) failed to reveal paroxysmal discharge, MEGs demonstrated localized high frequency magnetic activity (HFMA). Magnetic source imaging (MSI) depicted the accumulation of equivalent current dipole (ECD) originating from HFMA around the nidus, and the ECD localization agreed well with spike localization on intraoperative electrocorticography (ECoG). These areas corresponded with the areas of hypoperfusion on single photon emission tomography and the intraoperative laser Doppler flow meter. We discussed the application of MEG in estimating interictal paroxysmal activity sources in patients with AVM and addressed the questions of its reliability and validity in source localization.

Original language	English
Pages (from-to)	206-212
Number of pages	7
Journal	Neurosurgical Review
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/PL00011956
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Surgery
Clinical Neurology

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10.1007/PL00011956

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title = "Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation",

abstract = "Magnetoencephalographic (MEG) activities were recorded in five patients with cerebral arteriovenous malformation (AVM) who presented with epilepsy and no clinical history of intracranial hemorrhage, using a 37-channel DC superconducting quantum interference device (SQUID) system. While scalp-recorded electroencephalograms (EEG) failed to reveal paroxysmal discharge, MEGs demonstrated localized high frequency magnetic activity (HFMA). Magnetic source imaging (MSI) depicted the accumulation of equivalent current dipole (ECD) originating from HFMA around the nidus, and the ECD localization agreed well with spike localization on intraoperative electrocorticography (ECoG). These areas corresponded with the areas of hypoperfusion on single photon emission tomography and the intraoperative laser Doppler flow meter. We discussed the application of MEG in estimating interictal paroxysmal activity sources in patients with AVM and addressed the questions of its reliability and validity in source localization.",

author = "Takato Morioka and Shunji Nishio and Kei Hisada and Hiroshi Shigeto and Tomoya Yamamoto and Kiyotaka Fujii and Masashi Fukui",

note = "Funding Information: Acknowledgements We wish to thank Ms. Y. Somehara, BioMedical Division, Sumitomo Metal Industries, Ltd. for her technical assistance. This work was supported in part by grants for scientific research from the Japanese Ministry of Education, Science, Sports, and Culture (Nos. 08407043 and 09470297) and research grants from the Magnetic Health Science Foundation and the Japan Epilepsy Research Foundation.",

year = "2000",

doi = "10.1007/PL00011956",

language = "English",

volume = "23",

pages = "206--212",

journal = "Neurosurgical Review",

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T1 - Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation

AU - Morioka, Takato

AU - Nishio, Shunji

AU - Hisada, Kei

AU - Shigeto, Hiroshi

AU - Yamamoto, Tomoya

AU - Fujii, Kiyotaka

AU - Fukui, Masashi

N1 - Funding Information: Acknowledgements We wish to thank Ms. Y. Somehara, BioMedical Division, Sumitomo Metal Industries, Ltd. for her technical assistance. This work was supported in part by grants for scientific research from the Japanese Ministry of Education, Science, Sports, and Culture (Nos. 08407043 and 09470297) and research grants from the Magnetic Health Science Foundation and the Japan Epilepsy Research Foundation.

PY - 2000

Y1 - 2000

N2 - Magnetoencephalographic (MEG) activities were recorded in five patients with cerebral arteriovenous malformation (AVM) who presented with epilepsy and no clinical history of intracranial hemorrhage, using a 37-channel DC superconducting quantum interference device (SQUID) system. While scalp-recorded electroencephalograms (EEG) failed to reveal paroxysmal discharge, MEGs demonstrated localized high frequency magnetic activity (HFMA). Magnetic source imaging (MSI) depicted the accumulation of equivalent current dipole (ECD) originating from HFMA around the nidus, and the ECD localization agreed well with spike localization on intraoperative electrocorticography (ECoG). These areas corresponded with the areas of hypoperfusion on single photon emission tomography and the intraoperative laser Doppler flow meter. We discussed the application of MEG in estimating interictal paroxysmal activity sources in patients with AVM and addressed the questions of its reliability and validity in source localization.

AB - Magnetoencephalographic (MEG) activities were recorded in five patients with cerebral arteriovenous malformation (AVM) who presented with epilepsy and no clinical history of intracranial hemorrhage, using a 37-channel DC superconducting quantum interference device (SQUID) system. While scalp-recorded electroencephalograms (EEG) failed to reveal paroxysmal discharge, MEGs demonstrated localized high frequency magnetic activity (HFMA). Magnetic source imaging (MSI) depicted the accumulation of equivalent current dipole (ECD) originating from HFMA around the nidus, and the ECD localization agreed well with spike localization on intraoperative electrocorticography (ECoG). These areas corresponded with the areas of hypoperfusion on single photon emission tomography and the intraoperative laser Doppler flow meter. We discussed the application of MEG in estimating interictal paroxysmal activity sources in patients with AVM and addressed the questions of its reliability and validity in source localization.

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Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation

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