TY - JOUR
T1 - Neurodevelopmental Outcomes of High-Risk Preterm Infants
T2 - A Prospective Study in Japan
AU - Torio, Michiko
AU - Iwayama, Mariko
AU - Sawano, Toru
AU - Inoue, Hirosuke
AU - Ochiai, Masayuki
AU - Taira, Ryoji
AU - Yonemoto, Kousuke
AU - Ichimiya, Yuko
AU - Sonoda, Yuri
AU - Sasazuki, Momoko
AU - Ishizaki, Yoshito
AU - Sanefuji, Masafumi
AU - Yamane, Kenichi
AU - Yamashita, Hiroshi
AU - Torisu, Hiroyuki
AU - Kira, Ryutaro
AU - Hara, Toshiro
AU - Kanba, Shigenobu
AU - Sakai, Yasunari
AU - Ohga, Shouichi
N1 - Funding Information:
This study was supported by JSPS KAKENHI grant numbers JP17K16301 (M.T.), JP17K16300 (H.I.), JP18K15677 (Y. Sonoda), JP17K16271 (Y. Ichimiya) and JP19K08281 (Y. Sakai); a Health and Labour Sciences Research Grant on Evidence-based Early Diagnosis and Treatment Strategies for Neuroimmunological Diseases from the Ministry of Health, Labour and Welfare of Japan; Life Science Foundation of Japan; Takeda Science Foundation; The Mother and Child Health Foundation; The Japan Epilepsy Research Foundation; and Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics (Y.S.).
Publisher Copyright:
© 2022 American Academy of Neurology.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - ObjectivesTo determine the neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs, birth weight <1,500 g) after 9 years of follow-up.MethodsThis study prospectively recruited 224 VLBWIs born from 2003 to 2009 in Kyushu University Hospital, Japan. Comorbidities of neurocognitive impairment, epilepsy, and autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) were assessed at age 3, 6, and 9 years.ResultsNeurodevelopmental profiles were obtained from 185 (83%), 150 (67%), and 119 (53%) participants at age 3, 6, and 9 years, respectively. At age 9 years, 25 (21%) VLBWIs showed intelligence quotient (IQ) <70, 11 (9%) developed epilepsy, and 14 (12%) had a diagnosis of ASD/ADHD. The prevalence of epilepsy was higher in children with an IQ <70 at age 9 years than in those with an IQ ≥70 (44% vs 0%). In contrast, ASD/ADHD appeared at similar frequencies in children with an IQ <70 (16%) and ≥70 (11%). Perinatal complications and severe brain lesions on MRI were considered common perinatal risks for developmental delay and epilepsy but not for ASD/ADHD. Male sex was identified as a unique risk factor for ASD/ADHD.ConclusionThese data suggest that VLBWIs showed a higher prevalence of developmental delay, epilepsy, and ASD/ADHD at age 9 years than the general population. Distinct mechanisms might be involved in the pathogenic process of ASD/ADHD from those of developmental delay and epilepsy.
AB - ObjectivesTo determine the neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs, birth weight <1,500 g) after 9 years of follow-up.MethodsThis study prospectively recruited 224 VLBWIs born from 2003 to 2009 in Kyushu University Hospital, Japan. Comorbidities of neurocognitive impairment, epilepsy, and autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) were assessed at age 3, 6, and 9 years.ResultsNeurodevelopmental profiles were obtained from 185 (83%), 150 (67%), and 119 (53%) participants at age 3, 6, and 9 years, respectively. At age 9 years, 25 (21%) VLBWIs showed intelligence quotient (IQ) <70, 11 (9%) developed epilepsy, and 14 (12%) had a diagnosis of ASD/ADHD. The prevalence of epilepsy was higher in children with an IQ <70 at age 9 years than in those with an IQ ≥70 (44% vs 0%). In contrast, ASD/ADHD appeared at similar frequencies in children with an IQ <70 (16%) and ≥70 (11%). Perinatal complications and severe brain lesions on MRI were considered common perinatal risks for developmental delay and epilepsy but not for ASD/ADHD. Male sex was identified as a unique risk factor for ASD/ADHD.ConclusionThese data suggest that VLBWIs showed a higher prevalence of developmental delay, epilepsy, and ASD/ADHD at age 9 years than the general population. Distinct mechanisms might be involved in the pathogenic process of ASD/ADHD from those of developmental delay and epilepsy.
UR - http://www.scopus.com/inward/record.url?scp=85131175404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131175404&partnerID=8YFLogxK
U2 - 10.1212/CPJ.0000000000000920
DO - 10.1212/CPJ.0000000000000920
M3 - Article
AN - SCOPUS:85131175404
SN - 2163-0402
VL - 11
SP - 398
EP - 405
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 5
ER -