TY - JOUR
T1 - Neuroanatomical substrate of chronic psychosis in epilepsy
T2 - an MRI study
AU - Hirakawa, Noriaki
AU - Kuga, Hironori
AU - Hirano, Yoji
AU - Sato, Jinya
AU - Oribe, Naoya
AU - Nakamura, Itta
AU - Hirano, Shogo
AU - Ueno, Takefumi
AU - Oda, Yuko
AU - Togao, Osamu
AU - Hiwatashi, Akio
AU - Honda, Hiroshi
AU - Kanba, Shigenobu
AU - Onitsuka, Toshiaki
N1 - Funding Information:
Funding This work was supported in part by a Grant-in-Aid for Scientific Research [16 K10217 and C23591712 to T.O., 16H02666 and B25293252 to S.K., B22791129 and 15 K09836 to Y.H.], and the Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers from the Ministry of Education, Culture, Sports, Science, and Technology, Japan [S2208 to S.K. and T.O.]; a Research Grant from the Brain Science Foundation (Y.H.), Takeda Science Foundation (Y.H.) and SENSHIN Medical Research Foundation (Y.H. and T.O).
Publisher Copyright:
© 2019, The Author(s).
PY - 2020/10/1
Y1 - 2020/10/1
N2 - There may be different neural bases between subjects with epilepsy only (EP) and interictal chronic epilepsy psychosis (EPS). However, there have been few structural MRI studies of EPS. The current study was conducted to investigate the neural substrate of EPS. T1-weighted images were analyzed in 14 patients with EPS and 14 strictly-matched patients with EP. We conducted volume comparison in the whole brain using voxel-based morphometry (VBM). The VBM method revealed that EPS patients exhibited significantly reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus compared with EP patients (adjusted p = 0.029, FDR corrected q; k = 319 voxels). For clinical correlations, there were no significant associations between psychotic symptoms and gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus. VBM analysis revealed that reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus may be crucial regions for EPS.
AB - There may be different neural bases between subjects with epilepsy only (EP) and interictal chronic epilepsy psychosis (EPS). However, there have been few structural MRI studies of EPS. The current study was conducted to investigate the neural substrate of EPS. T1-weighted images were analyzed in 14 patients with EPS and 14 strictly-matched patients with EP. We conducted volume comparison in the whole brain using voxel-based morphometry (VBM). The VBM method revealed that EPS patients exhibited significantly reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus compared with EP patients (adjusted p = 0.029, FDR corrected q; k = 319 voxels). For clinical correlations, there were no significant associations between psychotic symptoms and gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus. VBM analysis revealed that reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus may be crucial regions for EPS.
UR - http://www.scopus.com/inward/record.url?scp=85061282848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061282848&partnerID=8YFLogxK
U2 - 10.1007/s11682-019-00044-4
DO - 10.1007/s11682-019-00044-4
M3 - Article
C2 - 30734915
AN - SCOPUS:85061282848
SN - 1931-7557
VL - 14
SP - 1382
EP - 1387
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 5
ER -
