Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship

Masafumi Kaneko; Koji Yamada; Tomofumi Miyamoto; Masanori Inagaki; Ryuichi Higuchi

doi:10.1248/cpb.55.462

Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship

Masafumi Kaneko, Koji Yamada, Tomofumi Miyamoto, Masanori Inagaki, Ryuichi Higuchi

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.

Original language	English
Pages (from-to)	462-463
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	3
DOIs	https://doi.org/10.1248/cpb.55.462
Publication status	Published - Mar 2007

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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10.1248/cpb.55.462

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abstract = "The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.",

author = "Masafumi Kaneko and Koji Yamada and Tomofumi Miyamoto and Masanori Inagaki and Ryuichi Higuchi",

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AU - Inagaki, Masanori

AU - Higuchi, Ryuichi

PY - 2007/3

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N2 - The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.

AB - The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.

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Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship

Abstract

All Science Journal Classification (ASJC) codes

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