TY - JOUR
T1 - Neural stem cells and regeneration of injured spinal cord
AU - Okano, Hideyuki
AU - Okada, Seiji
AU - Nakamura, Masaya
AU - Toyama, Yoshiaki
N1 - Funding Information:
We are grateful to Dr. Tadamitsu Kishimoto and Dr. Kazuyuki Yoshizaki at Osaka University and Dr. Yoshiuki Ohsugi at Chugai Pharmaceutical Company Ltd., for their continuous encouragement and supports. This work was supported by grants from the Japanese Ministry of Education, Sports and Culture of Japan to H.O., and a grant from the 21st century COE program of the Ministry of Education, Science and Culture of Japan to Keio University.
PY - 2005/11
Y1 - 2005/11
N2 - Recent progress in the stem cell biology has led much insight into new therapeutic interventions aiming for the regeneration of the damaged central nervous system. The major strategies can be classified into two subgroups: (1) activation of endogenous neural stem cells, and (2) cell transplantation therapies. In either of these strategies, it is crucial to understand the underlying mechanisms of maintenance, activation, and differentiation of neural stem cells and subsequent process, including the migration, survival, and functional maturation of differentiated cells. In this paper, we would like to summarize our recent findings on the therapeutic interventions of the injured spinal cord, especially focusing on the development of treatment for the acute phase of spinal cord injury with anti-interleukin (IL)-6 receptor blocking antibody.
AB - Recent progress in the stem cell biology has led much insight into new therapeutic interventions aiming for the regeneration of the damaged central nervous system. The major strategies can be classified into two subgroups: (1) activation of endogenous neural stem cells, and (2) cell transplantation therapies. In either of these strategies, it is crucial to understand the underlying mechanisms of maintenance, activation, and differentiation of neural stem cells and subsequent process, including the migration, survival, and functional maturation of differentiated cells. In this paper, we would like to summarize our recent findings on the therapeutic interventions of the injured spinal cord, especially focusing on the development of treatment for the acute phase of spinal cord injury with anti-interleukin (IL)-6 receptor blocking antibody.
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U2 - 10.1111/j.1523-1755.2005.00621.x
DO - 10.1111/j.1523-1755.2005.00621.x
M3 - Article
C2 - 16221167
AN - SCOPUS:30944442267
SN - 0085-2538
VL - 68
SP - 1927
EP - 1931
JO - Kidney International
JF - Kidney International
IS - 5
ER -