Neural stem cells and regeneration of injured spinal cord

Hideyuki Okano, Seiji Okada, Masaya Nakamura, Yoshiaki Toyama

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Recent progress in the stem cell biology has led much insight into new therapeutic interventions aiming for the regeneration of the damaged central nervous system. The major strategies can be classified into two subgroups: (1) activation of endogenous neural stem cells, and (2) cell transplantation therapies. In either of these strategies, it is crucial to understand the underlying mechanisms of maintenance, activation, and differentiation of neural stem cells and subsequent process, including the migration, survival, and functional maturation of differentiated cells. In this paper, we would like to summarize our recent findings on the therapeutic interventions of the injured spinal cord, especially focusing on the development of treatment for the acute phase of spinal cord injury with anti-interleukin (IL)-6 receptor blocking antibody.

Original languageEnglish
Pages (from-to)1927-1931
Number of pages5
JournalKidney International
Issue number5
Publication statusPublished - Nov 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology


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