TY - JOUR
T1 - Natural and forced neurogenesis in the adult brain
T2 - Mechanisms and their possible application to treat neurological disorders
AU - Matsuda, Taito
AU - Nakashima, Kinichi
N1 - Funding Information:
This work was supported by Grant-in-Aid for Young Scientists (B)18K14820. Review article for the Japan Neuroscience Society Young Investigator Award 2020.
Publisher Copyright:
© 2020 Elsevier B.V. and Japan Neuroscience Society
PY - 2021/5
Y1 - 2021/5
N2 - Neural stem cells (NSCs) in the adult hippocampus generate new neurons via a process referred to as neurogenesis, supporting cognitive functions. Since altered neurogenesis has been reportedly associated with several diseases such as epilepsy, the molecular basis of NSC activity is an important focus in the study of neurogenesis. Furthermore, facilitation of neurogenesis in the injured brain would be an ideal approach to replenish lost neurons for damage recovery. However, natural neurogenesis by endogenous NSCs in the adult brain is insufficient for complete recovery after severe injury. Recent advances in understanding forced neurogenesis from brain-resident non-neuronal cells by direct reprogramming and clearing hurdles to achieve it have improved the ability to replace damaged neurons in the brain. In this review, we describe molecular mechanisms underlying natural and forced neurogenesis, and discuss future directions for treatments of diseases in the central nervous system.
AB - Neural stem cells (NSCs) in the adult hippocampus generate new neurons via a process referred to as neurogenesis, supporting cognitive functions. Since altered neurogenesis has been reportedly associated with several diseases such as epilepsy, the molecular basis of NSC activity is an important focus in the study of neurogenesis. Furthermore, facilitation of neurogenesis in the injured brain would be an ideal approach to replenish lost neurons for damage recovery. However, natural neurogenesis by endogenous NSCs in the adult brain is insufficient for complete recovery after severe injury. Recent advances in understanding forced neurogenesis from brain-resident non-neuronal cells by direct reprogramming and clearing hurdles to achieve it have improved the ability to replace damaged neurons in the brain. In this review, we describe molecular mechanisms underlying natural and forced neurogenesis, and discuss future directions for treatments of diseases in the central nervous system.
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U2 - 10.1016/j.neures.2020.05.011
DO - 10.1016/j.neures.2020.05.011
M3 - Review article
C2 - 32497571
AN - SCOPUS:85086333636
SN - 0168-0102
VL - 166
SP - 1
EP - 11
JO - Neuroscience Research
JF - Neuroscience Research
ER -