Abstract
Background and Aim: To clarify the clinicoepidemiological characteristics of immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with malignancy, a nationwide epidemiological survey was conducted. Methods: Immunoglobulin G4-related disease patients with malignancy who had visited selected hospitals in Japan were surveyed. The study consisted of two stages: the number of IgG4-RD patients with malignancy was estimated by the first questionnaire and their clinicoepidemiological characteristics were assessed by the second questionnaire. Results: The frequencies of autoimmune pancreatitis (AIP), IgG4-related sialadenitis, IgG4-related eye disease, IgG4-related kidney disease, and IgG4-related retroperitoneal fibrosis were 44.7%, 20.8%, 14.0%, 5.16%, and 5.12%, respectively. The overall prevalence of malignant disease in IgG4-RD cases was estimated to be 10 900 per 100 000 cases, which was significantly higher than that of malignant disease in the general population. The prevalence of malignant lymphoma in IgG4-RD cases was the highest and was estimated to be 1985 per 100 000 cases. IgG4-related kidney disease had the highest frequency of malignant disease (17.1%). In data from 200 patients, 61 (30.5%) cases of cancer were found 2 years or more before the IgG4-RD diagnosis, 92 cases (46%) during the 1 year preceding or following IgG4-RD diagnosis, and 62 cases of cancer (31%) 2 or more years following IgG4-RD diagnosis. Conclusions: The nationwide survey for IgG4-RD with malignancy in Japan showed that IgG4-RD may be related with malignant diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 1022-1033 |
| Number of pages | 12 |
| Journal | Journal of Gastroenterology and Hepatology (Australia) |
| Volume | 37 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2022 |
All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
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In: Journal of Gastroenterology and Hepatology (Australia), Vol. 37, No. 6, 06.2022, p. 1022-1033.
Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Nationwide epidemiological survey of immunoglobulin G4-related disease with malignancy in Japan
AU - The Research Committee for an Intractable Disease of IgG4-related disease
AU - Sumimoto, Kimi
AU - Uchida, Kazushige
AU - Ikeura, Tsukasa
AU - Hirano, Kenji
AU - Yamamoto, Motohisa
AU - Takahashi, Hiroki
AU - Nishino, Takayoshi
AU - Mizushima, Ichiro
AU - Kawano, Mitsuhiro
AU - Kamisawa, Terumi
AU - Saeki, Takako
AU - Maguchi, Hiroyuki
AU - Ushijima, Tomoyuki
AU - Shiokawa, Masahiro
AU - Seno, Hiroshi
AU - Goto, Hiroshi
AU - Nakamura, Seiji
AU - Okazaki, Kazuichi
N1 - Funding Information: This work was supported by the research program for intractable diseases from the Ministry of Health, Labour and Welfare of Japanese Government. Financial support: Funding Information: The authors are grateful to the Research Committee for an Intractable Disease of IgG4-related disease who kindly replied to the questionnaires. The Research Committee for an Intractable Disease of IgG4-related disease are as follows: Department of Gastroenterology, Tokyo Takanawa Hospital, Tokyo (Kenji Hirano); The Institute of Medical Science, the University of Tokyo, Tokyo (Motohisa Yamamoto); Department of Rheumatology, Sapporo Medical University School of Medicine, Hokkaido (Hiroki Takahashi); Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center, Tokyo (Takayoshi Nishino); Division of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Ishikawa (Ichiro Mizushima and Mitsuhiro Kawano); Tokyo Metropolitan Komagome Hospital, Tokyo (Terumi Kamisawa); Department of Internal Medicine, Nagaoka Red Cross Hospital, Niigata (Takako Saeki); Center for Gastroenterology, Teine-Keijinkai Hospital, Hokkaido (Hiroyuki Maguchi); Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka (Tomoyuki Ushijima); Division of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto (Masahiro Shiokawa and Hiroshi Seno); Department of Ophthalmology, Tokyo Medical University, Tokyo (Hiroshi Goto); Division of Gastroenterology, Tohoku University, Graduate School of Medicine, Miyagi; Division of Hematology and Immunology, Medicine, Kanazawa Medical University, Ishikawa; Department of Gastroenterology, Nagano Municipal Hospital, Nagano; Department of Gastroenterology, Gifu University Hospital, Gifu; Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya; Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto; The First Department of Medicine, Wakayama Medical University, Wakayama; Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; A Health Administration Center, University of Toyama, Toyama; Department of Internal Medicine, Nagoya Medical Center, National Hospital Organization, Nagoya; Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Mie; Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime; Department of Urology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Ophthalmology, Oita University, Oita; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya; Department of Rheumatology, Shinko Hospital, Hyogo; Department of Respiratory Medicine, Iwate Prefectural Central Hospital, Iwate; Department of Medicine, Asahikawa Medical University, Hokkaido; Division of General Medicine, Department of Internal Medicine, Nihon University, Tokyo; Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo; Department of Urology, Toranomon Hospital, Tokyo; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo; Department of Urology, Cancer Institute Hospital, Tokyo; Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo; Department of Nephrology, National Center for Global Health and Medicine, Tokyo; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo; Department of Ophthalmology, Teikyo University School of Medicine, Tokyo; Division of Respiratory Diseases, Saint Marianna University School of Medicine, Kanagawa; Department of Rheumatology, National Hospital Organization Yokohama Medical Center, Kanagawa; Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba; Department of Gastroenterology, Kameda Medical Center, Chiba; Department of Gastroenterology, Jichi Medical University, Tochigi; Department of Ophthalmology, Saitama Red Cross Hospital, Saitama; Department of Nephrology, National Hospital Organization Nagoya Medical Center, Nagoya; Department of Nephrology and Kidney Transplant Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya; Department of Nephrology, Fujita Health University School of Medicine, Aichi; Department of Urology, Gifu Municipal Hospital, Gifu; Department of Cardiology and Respirology, Gifu University Graduate School of Medicine, Gifu; Department of Hematology, Otsu City Hospital, Shiga; Department of Otorhinolaryngology, Shiga University of Medical Science, Shiga; Department of Respiratory Medicine, Saiseikai Nakatsu Hospital, Osaka; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka; Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka; Department of Internal Medicine, Division of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Hyogo; Department of Respiratory Medicine, National Hospital Organization Himeji Medical Center, Hyogo; Department of Internal Medicine, Fukuyama City Hospital, Hiroshima; Department of Gastroenterology, Hiroshima Prefectural Hospital, Hiroshima; Department of Urology, National Hospital Organization Kure Medical Center, Hiroshima; Department of Gastroenterology and Hepatology, JA Hiroshima General Hospital, Hiroshima; Department of Otorhinolaryngology, National Hospital Organization Kanmon Medical Center, Yamaguchi; Department of Respiratory Medicine and Rheumatology, Tokushima University Graduate School of Medical Sciences, Tokushima; Department of Otorhinolaryngology, Japan Community Healthcare Organization (JCHO), Kyusyu Hospital, Fukuoka; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Fukuoka; Department of Internal Medicine, Karatsu Red Cross Hospital, Saga; Sasebo City General Hospital, Nagasaki; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto; Department of Respiratory Medicine, Tomishiro Central Hospital, Okinawa; Department of Internal Medicine, Tomishiro Central Hospital, Okinawa; Department of Hematology and Oncology, University of Fukui Hospital, Fukui; Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata; Department of Ophthalmology, Fukushima Medical University, Fukushima; Department of Urology, Hoshi General Hospital, Fukushima; Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Gifu; Department of Ophthalmology, Osaki Citizen Hospital, Miyagi; Department of Otolaryngology-Head and Neck Surgery, Yamagata University Faculty of Medicine, Yamagata; Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Tokyo; Department of Gastroenterology, Keio University School of Medicine, Tokyo; Department of Diagnostic Pathology, Dokkyo University School of Medicine, Tochigi; Department of Gastroenterology, Banbuntane Hotokukai Hospital, Fujita Health University School of Medicine, Nagoya; Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya; Department of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto; Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto; Department of Nephrology, National Hospital Organization Kyoto Medical Center, Kyoto; Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama; Department of Endocrinology and Rheumatology, Kurashiki Central Hospital, Okayama; Department of Nephrology, Kurashiki Central Hospital, Okayama; Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki; Department of Gastroenterology, Kanazawa Medical University, Ishikawa; Department of Otolaryngology, Head and Neck Surgery, University of Toyama, Toyama; Department of Ophthalmology, Niigata University Graduate School of Medical and Dental Sciences, Niigata; Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata; and University Graduate School of Medical and Dental Sciences, Niigata. Publisher Copyright: © 2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
PY - 2022/6
Y1 - 2022/6
N2 - Background and Aim: To clarify the clinicoepidemiological characteristics of immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with malignancy, a nationwide epidemiological survey was conducted. Methods: Immunoglobulin G4-related disease patients with malignancy who had visited selected hospitals in Japan were surveyed. The study consisted of two stages: the number of IgG4-RD patients with malignancy was estimated by the first questionnaire and their clinicoepidemiological characteristics were assessed by the second questionnaire. Results: The frequencies of autoimmune pancreatitis (AIP), IgG4-related sialadenitis, IgG4-related eye disease, IgG4-related kidney disease, and IgG4-related retroperitoneal fibrosis were 44.7%, 20.8%, 14.0%, 5.16%, and 5.12%, respectively. The overall prevalence of malignant disease in IgG4-RD cases was estimated to be 10 900 per 100 000 cases, which was significantly higher than that of malignant disease in the general population. The prevalence of malignant lymphoma in IgG4-RD cases was the highest and was estimated to be 1985 per 100 000 cases. IgG4-related kidney disease had the highest frequency of malignant disease (17.1%). In data from 200 patients, 61 (30.5%) cases of cancer were found 2 years or more before the IgG4-RD diagnosis, 92 cases (46%) during the 1 year preceding or following IgG4-RD diagnosis, and 62 cases of cancer (31%) 2 or more years following IgG4-RD diagnosis. Conclusions: The nationwide survey for IgG4-RD with malignancy in Japan showed that IgG4-RD may be related with malignant diseases.
AB - Background and Aim: To clarify the clinicoepidemiological characteristics of immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with malignancy, a nationwide epidemiological survey was conducted. Methods: Immunoglobulin G4-related disease patients with malignancy who had visited selected hospitals in Japan were surveyed. The study consisted of two stages: the number of IgG4-RD patients with malignancy was estimated by the first questionnaire and their clinicoepidemiological characteristics were assessed by the second questionnaire. Results: The frequencies of autoimmune pancreatitis (AIP), IgG4-related sialadenitis, IgG4-related eye disease, IgG4-related kidney disease, and IgG4-related retroperitoneal fibrosis were 44.7%, 20.8%, 14.0%, 5.16%, and 5.12%, respectively. The overall prevalence of malignant disease in IgG4-RD cases was estimated to be 10 900 per 100 000 cases, which was significantly higher than that of malignant disease in the general population. The prevalence of malignant lymphoma in IgG4-RD cases was the highest and was estimated to be 1985 per 100 000 cases. IgG4-related kidney disease had the highest frequency of malignant disease (17.1%). In data from 200 patients, 61 (30.5%) cases of cancer were found 2 years or more before the IgG4-RD diagnosis, 92 cases (46%) during the 1 year preceding or following IgG4-RD diagnosis, and 62 cases of cancer (31%) 2 or more years following IgG4-RD diagnosis. Conclusions: The nationwide survey for IgG4-RD with malignancy in Japan showed that IgG4-RD may be related with malignant diseases.
UR - http://www.scopus.com/inward/record.url?scp=85132050003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132050003&partnerID=8YFLogxK
U2 - 10.1111/jgh.15809
DO - 10.1111/jgh.15809
M3 - Article
C2 - 35229347
AN - SCOPUS:85132050003
SN - 0815-9319
VL - 37
SP - 1022
EP - 1033
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
IS - 6
ER -