Narrative review of local prostate and metastasis-directed radiotherapy in the treatment of metastatic prostate cancer

Naoki Terada, Rihito Aizawa, Keiji Nihei, Masaki Shiota, Takahiro Kojima, Takahiro Kimura, Takahiro Inoue, Hiroshi Kitamura, Mikio Sugimoto, Hiroyuki Nishiyama, Takashi Mizowaki, Toshiyuki Kamoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The role of local treatment in patients with de novo metastatic prostate cancer is controversial. In population-based retrospective studies, metastatic prostate cancer patients who received local treatment with prostate radiotherapy showed a better prognosis than those who did not. In addition, several prospective randomized studies demonstrated that prostate radiotherapy achieves a survival benefit for patients with oligo-metastasis. Moreover, the efficacy of metastasis-directed radiotherapy was evaluated, revealing a potential benefit for patients with oligo-metastasis. Importantly, these radiotherapies may reduce the occurrence of symptomatic local events. In this review, the rationale, efficacy and future perspectives for local prostate and metastasis-directed radiotherapy in the treatment of metastatic prostate cancer were described and summarized.

Original languageEnglish
Pages (from-to)633-641
Number of pages9
JournalJapanese journal of clinical oncology
Volume52
Issue number6
DOIs
Publication statusPublished - Jun 1 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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