Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis

Noritada Kaji, Takao Yasui, Manabu Tokeshi, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingChapter


Recent development of nanofluidic devices using nanopillars, nanowires, and nanoballs for high-performance biomolecules analysis are reviewed in this chapter. Two approaches, "top-down" fabrication techniques and "bottom-up" self-assemble techniques, were applied to construct nanospace inside microchannels, and various biomolecules including DNA, RNA and proteins were successfully separated within a few seconds. These separation techniques enabled high throughput analysis that had never achieved by natural or synthetic polymers and explored a new bioanalytical field based on molecular dynamics in nanospace. Hybrid use of the both approaches might be promising for future home diagnostic devices and clinical applications.

Original languageEnglish
Title of host publicationNanofluidics, 2nd Edition
EditorsPaul O'Brien, Joshua Edel, Aleksandar Ivanov, MinJun Kim
PublisherRoyal Society of Chemistry
Number of pages23
ISBN (Electronic)9781782621713, 9781849734042
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameRSC Nanoscience and Nanotechnology
ISSN (Print)1757-7136
ISSN (Electronic)1757-7144

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • General Chemistry
  • Atomic and Molecular Physics, and Optics
  • General Materials Science
  • General Engineering


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