N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: The hisayama study

Yasufumi Doi, Toshiharu Ninomiya, Jun Hata, Yoichiro Hirakawa, Naoko Mukai, Fumie Ikeda, Masayo Fukuhara, Masanori Iwase, Yutaka Kiyohara

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41 Citations (Scopus)


Objective-Few studies have examined the association between natriuretic peptides and the incidence of cardiovascular disease (CVD) in Asian populations. Methods and results-A total of 3104 community-dwelling Japanese individuals aged 40 years without history of CVD were followed up for 5 years. A total of 127 CVD events were identified. The age-and sex-adjusted incidence of CVD increased with increasing N-terminal pro-brain natriuretic peptide (NT-proBNP) levels (<55, 55-124, 125-399, and 400 pg/mL) at baseline and was significantly higher even in subjects with a modest increase. This association remained robust even after adjustment for other potential risk factors (55-124 pg/mL: multivariate-adjusted hazard ratio=1.85 [95% CI 1.07-3.18], P=0.03; 125-399 pg/mL: 2.98 [95% CI 1.65-5.39], P<0.001; 400 pg/mL: 4.54 [95% CI 2.22-9.29], P<0.001). The multivariate-adjusted hazard ratios for the development of total CVD and its subtypes, coronary heart disease and stroke, were significantly increased by a 1 SD increment of the log NT-proBNP concentrations and were nearly equal among CVD subtypes. Similar findings were observed for stroke subtypes of ischemic stroke and intracerebral hemorrhage but not subarachnoid hemorrhage. The effects of the 1 SD increment in log NT-proBNP values were comparable in subjects with and without other cardiovascular risk factors, except for sex. The area under the receiver operating characteristic curve was significantly (P=0.006) increased by adding NT-proBNP values to the model including other potential risk factors. Conclusion-Elevated NT-proBNP levels were shown to be a significant risk factor for the development of CVD and its subtypes in a general Japanese population, independently of other cardiovascular risk factors.

Original languageEnglish
Pages (from-to)2997-3003
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number12
Publication statusPublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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