N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells

Yuichi Murakami; Kosuke Watari; Tomohiro Shibata; Manami Uba; Hiroki Ureshino; Akihiko Kawahara; Hideyuki Abe; Hiroto Izumi; Naofumi Mukaida; Michihiko Kuwano; Mayumi Ono

doi:10.1074/jbc.M113.472068

N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells

Yuichi Murakami
, Kosuke Watari
, Tomohiro Shibata
, Manami Uba
, Hiroki Ureshino
, Akihiko Kawahara
, Hideyuki Abe
, Hiroto Izumi
, Naofumi Mukaida
, Michihiko Kuwano
, Mayumi Ono

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.

Original language	English
Pages (from-to)	25025-25037
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.472068
Publication status	Published - Aug 30 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.472068

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Murakami, Y., Watari, K., Shibata, T., Uba, M., Ureshino, H., Kawahara, A., Abe, H., Izumi, H., Mukaida, N., Kuwano, M., & Ono, M. (2013). N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells. Journal of Biological Chemistry, 288(35), 25025-25037. https://doi.org/10.1074/jbc.M113.472068

N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells. / Murakami, Yuichi; Watari, Kosuke; Shibata, Tomohiro et al.
In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25025-25037.

Research output: Contribution to journal › Article › peer-review

Murakami, Y, Watari, K, Shibata, T, Uba, M, Ureshino, H, Kawahara, A, Abe, H, Izumi, H, Mukaida, N, Kuwano, M & Ono, M 2013, 'N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells', Journal of Biological Chemistry, vol. 288, no. 35, pp. 25025-25037. https://doi.org/10.1074/jbc.M113.472068

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title = "N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells",

abstract = "Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.",

author = "Yuichi Murakami and Kosuke Watari and Tomohiro Shibata and Manami Uba and Hiroki Ureshino and Akihiko Kawahara and Hideyuki Abe and Hiroto Izumi and Naofumi Mukaida and Michihiko Kuwano and Mayumi Ono",

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AU - Watari, Kosuke

AU - Shibata, Tomohiro

AU - Uba, Manami

AU - Ureshino, Hiroki

AU - Kawahara, Akihiko

AU - Abe, Hideyuki

AU - Izumi, Hiroto

AU - Mukaida, Naofumi

AU - Kuwano, Michihiko

AU - Ono, Mayumi

PY - 2013/8/30

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N2 - Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.

AB - Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.

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N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells

Abstract

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