TY - JOUR
T1 - N-confused porphyrin possessing glucamine-appendants
T2 - Aggregation and acid/base properties in aqueous media
AU - Ikawa, Yoshiya
AU - Ogawa, Hiroaki
AU - Harada, Hiroyuki
AU - Furuta, Hiroyuki
N1 - Funding Information:
This work was partly supported by Grants-in-Aid for Young Scientists (A) (No.18685020 to Y.I.), Exploratory Research (No.19657071 to Y.I.), and the Global COE program, “Science for Future Molecular Systems” (to H.F.) from the Ministry of Education, Culture, Science, Sports and Technology of Japan.
PY - 2008/12/15
Y1 - 2008/12/15
N2 - A water-soluble derivative of N-confused porphyrin (NCP: 5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin) was synthesized by introducing glucamine groups at the para-position of meso-aryl groups. The tetraglucamine-appended NCP (TG-NCP) exists as monocation in aqueous solution containing 6 mM sodium dodecyl sulfate (SDS) but exists as freebase to form aggregates in pure water. These properties are distinct from those of corresponding regular porphyrin, which exists as freebase in the micellar solution and practically insoluble in water.
AB - A water-soluble derivative of N-confused porphyrin (NCP: 5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin) was synthesized by introducing glucamine groups at the para-position of meso-aryl groups. The tetraglucamine-appended NCP (TG-NCP) exists as monocation in aqueous solution containing 6 mM sodium dodecyl sulfate (SDS) but exists as freebase to form aggregates in pure water. These properties are distinct from those of corresponding regular porphyrin, which exists as freebase in the micellar solution and practically insoluble in water.
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U2 - 10.1016/j.bmcl.2008.10.079
DO - 10.1016/j.bmcl.2008.10.079
M3 - Article
C2 - 18993069
AN - SCOPUS:56249141087
SN - 0960-894X
VL - 18
SP - 6394
EP - 6397
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 24
ER -