TY - JOUR
T1 - Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment
AU - Sekiya, Sayaka
AU - Miura, Shizuka
AU - Matsuda-Ito, Kanae
AU - Suzuki, Atsushi
N1 - Funding Information:
We thank Drs. Shinichi Aizawa and Frank Costantini for providing mice, and Yuuki Honda, Mayumi Yamamoto, Nanako Goto, Chiaki Kaieda, Masato Tanaka, and Kanako Motomura for excellent technical assistance. This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Japan Society for the Promotion of Science (grant numbers 23112002, 25713014, and 16H01850), Health Labor Sciences Research Grants in Japan, and the Core Research for Evolutional Science and Technology Program of the Japan Agency for Medical Research and Development (AMED-CREST).
Publisher Copyright:
© 2016 The Authors
PY - 2016/12/13
Y1 - 2016/12/13
N2 - Hepatic progenitor cells (HPCs) appear in response to several types of chronic injury in the human and rodent liver that often develop into liver fibrosis, cirrhosis, and primary liver cancers. However, the contribution of HPCs to the pathogenesis and progression of such liver diseases remains controversial. HPCs are generally defined as cells that can differentiate into hepatocytes and cholangiocytes. In this study, however, we found that HPCs isolated from the chronically injured liver can also give rise to myofibroblasts as a third type of descendant. While myofibroblast differentiation from HPCs is not significant in culture, during tumor development, HPCs can contribute to the formation of the tumor microenvironment by producing abundant myofibroblasts that might form a niche for tumor growth and survival. Thus, HPCs can be redefined as cells with a potential for differentiation into myofibroblasts that is specifically activated during tumor formation.
AB - Hepatic progenitor cells (HPCs) appear in response to several types of chronic injury in the human and rodent liver that often develop into liver fibrosis, cirrhosis, and primary liver cancers. However, the contribution of HPCs to the pathogenesis and progression of such liver diseases remains controversial. HPCs are generally defined as cells that can differentiate into hepatocytes and cholangiocytes. In this study, however, we found that HPCs isolated from the chronically injured liver can also give rise to myofibroblasts as a third type of descendant. While myofibroblast differentiation from HPCs is not significant in culture, during tumor development, HPCs can contribute to the formation of the tumor microenvironment by producing abundant myofibroblasts that might form a niche for tumor growth and survival. Thus, HPCs can be redefined as cells with a potential for differentiation into myofibroblasts that is specifically activated during tumor formation.
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U2 - 10.1016/j.stemcr.2016.11.002
DO - 10.1016/j.stemcr.2016.11.002
M3 - Article
C2 - 27916538
AN - SCOPUS:85004088963
SN - 2213-6711
VL - 7
SP - 1130
EP - 1139
JO - Stem Cell Reports
JF - Stem Cell Reports
IS - 6
ER -
