Myofibroblasts and inflammatory cells as players of cardiac fibrosis

Hitoshi Kurose, Supachoke Mangmool

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)


On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate inflammatory responses that play important roles in cardiac remodeling including fibrosis. Fibrosis is an excess accumulation of extracellular collagen. Currently, drugs used to treat cardiac fibrosis are not commercially available. Myofibroblasts are responsible for the production and secretion of collagen. Infiltrating inflammatory cells interact with fibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities of myofibroblasts. Regulation of collagen production is critical for modulating the progression of fibrosis. Hence, the manipulation of activities of inflammatory cells and myofibroblasts will provide promising therapeutic targets for treatment of cardiac fibrosis.

Original languageEnglish
Pages (from-to)1100-1113
Number of pages14
JournalArchives of Pharmacal Research
Issue number8
Publication statusPublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


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