TY - JOUR
T1 - Murine model of IgE production with a predominant Th2-response by feeding protein antigen without adjuvants
AU - Ito, Kazue
AU - Inagaki-Ohara, Kyoko
AU - Murosaki, Shinji
AU - Nishimura, Hitoshi
AU - Shimokata, Tomoya
AU - Torii, Shinnpei
AU - Matsuda, Tukasa
AU - Yoshikai, Yasunobu
PY - 1997/12
Y1 - 1997/12
N2 - Stimulation of systemic antigen-specific IgE production plays an important role in the mediation of food allergy; however, the mechanism of IgE production against food antigens is not fully understood. The development of relevant animal models may help to elucidate the pathogenesis of food allergy. We here show that DBA/2 mice receiving a casein diet without any adjuvant produced high levels of IgE specific for casein, accompanied by predominant Th2-like responses in liver lymphocytes, mesenteric lymph node cells and spleen cells. This model of IgE production produced by feeding protein antigen as a constituent of the diet can be applied to investigate the mechanism of IgE production and to develop reagents for controlling food allergy.
AB - Stimulation of systemic antigen-specific IgE production plays an important role in the mediation of food allergy; however, the mechanism of IgE production against food antigens is not fully understood. The development of relevant animal models may help to elucidate the pathogenesis of food allergy. We here show that DBA/2 mice receiving a casein diet without any adjuvant produced high levels of IgE specific for casein, accompanied by predominant Th2-like responses in liver lymphocytes, mesenteric lymph node cells and spleen cells. This model of IgE production produced by feeding protein antigen as a constituent of the diet can be applied to investigate the mechanism of IgE production and to develop reagents for controlling food allergy.
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U2 - 10.1002/eji.1830271243
DO - 10.1002/eji.1830271243
M3 - Article
C2 - 9464832
AN - SCOPUS:0031444429
SN - 0014-2980
VL - 27
SP - 3427
EP - 3437
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 12
ER -