Multiple mechanisms for p27Kip1 translocation and degradation

Etsuo Susaki, Keiichi I. Nakayama

Research output: Contribution to journalReview articlepeer-review

43 Citations (Scopus)


The nuclear export and rapid degradation of p27Kip1 at the G0-G1 transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G0-G 1 transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G 1 progression.

Original languageEnglish
Pages (from-to)3015-3020
Number of pages6
JournalCell Cycle
Issue number24
Publication statusPublished - Dec 15 2007

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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