Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

Koji Shinoda; Hideaki Asahara; Taira Uehara; Katsue Miyoshi; Satoshi O. Suzuki; Toru Iwaki; Jun Ichi Kira

doi:10.1177/1352458514533845

Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

Koji Shinoda, Hideaki Asahara, Taira Uehara, Katsue Miyoshi, Satoshi O. Suzuki, Toru Iwaki, Jun Ichi Kira

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.

Original language	English
Pages (from-to)	252-254
Number of pages	3
Journal	Multiple Sclerosis Journal
Volume	21
Issue number	2
DOIs	https://doi.org/10.1177/1352458514533845
Publication status	Published - Feb 17 2015

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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title = "Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection",

abstract = "We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.",

author = "Koji Shinoda and Hideaki Asahara and Taira Uehara and Katsue Miyoshi and Suzuki, {Satoshi O.} and Toru Iwaki and Kira, {Jun Ichi}",

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AU - Shinoda, Koji

AU - Asahara, Hideaki

AU - Uehara, Taira

AU - Miyoshi, Katsue

AU - Suzuki, Satoshi O.

AU - Iwaki, Toru

AU - Kira, Jun Ichi

PY - 2015/2/17

Y1 - 2015/2/17

N2 - We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.

AB - We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.

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Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

Abstract

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