Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging

Kazuma Tsuboi; Shinya Fukuba; Ryo Naraoka; Katsuhiko Fujita; Kotaro Kajikawa

doi:10.1364/AO.46.004486

Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging

Kazuma Tsuboi, Shinya Fukuba, Ryo Naraoka, Katsuhiko Fujita, Kotaro Kajikawa

Department of Advanced Device Materials

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 μm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.

Original language	English
Pages (from-to)	4486-4490
Number of pages	5
Journal	Applied Optics
Volume	46
Issue number	20
DOIs	https://doi.org/10.1364/AO.46.004486
Publication status	Published - Jul 10 2007

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

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abstract = "What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 μm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.",

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AU - Kajikawa, Kotaro

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AB - What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 μm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.

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Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging

Abstract

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