Multi-institutional analysis of early squamous cell carcinoma of the hypopharynx treated with radical radiotherapy

Katsumasa Nakamura, Yoshiyuki Shioyama, Mitsuhiko Kawashima, Yoshihiro Saito, Naoki Nakamura, Kensei Nakata, Masato Hareyama, Takahiro Takada, Kumiko Karasawa, Toshiichi Watanabe, Atsunori Yorozu, Hiroyuki Tachibana, Gen Suzuki, Naofumi Hayabuchi, Takashi Toba, Shogo Yamada

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57 Citations (Scopus)


Purpose: To analyze the outcomes of patients with early hypopharyngeal cancer treated with radical radiotherapy (RT). Methods and Materials: Ten institutions combined the data from 115 patients with Stage I-II hypopharyngeal squamous cell carcinoma treated with definitive RT between 1990 and 2001. The median patient age was 67 years; 99 patients were men and 16 were women. Of the 115 patients, 39 had Stage I and 76 had Stage II disease. Conventional fractionation was used in 98 patients and twice-daily RT in 17 patients; chemotherapy was combined with RT in 57 patients. The median follow-up period was 47 months. Results: The overall and disease-specific 5-year survival rate for 95 patients without synchronous malignancies was 66.0% and 77.4%, respectively. The 5-year disease-specific survival rate by T stage was 95.8% for patients with T1 disease and 70.1% for patients with T2 disease (p = 0.02). Of the 115 patients, local control with laryngeal voice preservation was achieved in 34 of 39 patients with T1 lesions, including 7 patients successfully salvaged, and in 56 of 76 patients with T2 lesions. Sixty-five patients (56.5%) had synchronous or metachronous cancers. Of the 115 patients, 19 died of hypopharyngeal cancer, 10 died of second primary cancers, and 14 died of other causes during the study and follow-up periods. Conclusions: Patients with early hypopharyngeal cancer tended to have a good prognosis after RT. However, second malignancies had an adverse effect on the overall outcomes of patients with early hypopharyngeal cancer.

Original languageEnglish
Pages (from-to)1045-1050
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number4
Publication statusPublished - Jul 15 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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