Mulberry anthracnose antagonists (iturins) produced by Bacillus amyloliquefaciens RC-2

Syuntaro Hiradate, Shigenobu Yoshida, Hajime Sugie, Hiroshi Yada, Yoshiharu Fujii

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)


Bacillus amyloliquefaciens strain RC-2 produced seven antifungal compounds (1-7) secreted into the culture filtrate. These compounds inhibited the development of mulberry anthracnose caused by the fungus, Colletotrichum dematium. Chemical structural analyses by NMR and FAB-MS revealed that all these compounds were iturins (cyclic peptides with the following sequence: L-Asn → D-Tyr → D-Asn → L-Gln → L-Pro → D-Asn → L-Ser → D-β-amino acid →) and compounds 1-6 are identical to iturins A-2-A-7, respectively. Compound 7 (iturin A-8) is a new iturin, which has a -(CH2)10CH(CH3)CH2CH3 group as a side chain in the β-amino acid in the molecule.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
Issue number6
Publication statusPublished - Nov 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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