Mucinous cystadenoma in the upper lip: Report of two cases

Tomohiro Yamada, Mayu Takahashi, Manabu Matsumoto, Makoto Toi, Seiji Ohno, Naoya Kitamura, Eri Sasabe, Tetsuya Yamamoto

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3 Citations (Scopus)


Mucinous cystadenoma of the salivary gland is a very rare disease, and only a few cases have been reported. We report here 2 cases of mucinous cystadenoma in the upper lip. The first case was a 57-year-old man and the second was a 42-year-old woman. The tumors were painless nodules with a smooth-surfaced mucosa, and surgical excisions were performed. Histologically, the tumors were surrounded by a fibrous capsule and were composed of multiple cysts lined with columnar epithelial cells. The tumor cells contain mucous substances that reacted with periodic acid-Schiff base and Alcian blue. Immunohistochemical staining reveal ed that the tumor cells expressed cytokeratin (AE1/3 and CK7), but their immunoreactivity with MIB-1 (Ki-67) was less than 3%. They had negative immunoreactivity for neuroectoderm markers, S-100 protein, and myoepithelial markers, p63, α-smooth muscle actin, and calponin, except for the accompanying myoepithelial-like cells. No recurrences were noted after surgery at 7 years and 1 year, respectively.

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number4
Publication statusPublished - Jun 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine


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