mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

Yurika Mizobe; Daichi Oikawa; Shoichiro Tsuyama; Yoriko Akimoto; Kousuke Hamasu; Eiichiro Onitsuka; Mikako Sato; Yoshihisa Takahata; Fumiki Morimatsu; Mitsuhiro Furuse

doi:10.1271/bbb.80450

mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

Yurika Mizobe, Daichi Oikawa, Shoichiro Tsuyama, Yoriko Akimoto, Kousuke Hamasu, Eiichiro Onitsuka, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

Animal and Marine Bioresource Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

Original language	English
Pages (from-to)	3067-3070
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	72
Issue number	11
DOIs	https://doi.org/10.1271/bbb.80450
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1271/bbb.80450

Cite this

@article{9b1bc8ad0ba944fab3249c57de18e4c9,

title = "mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin",

abstract = "Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.",

author = "Yurika Mizobe and Daichi Oikawa and Shoichiro Tsuyama and Yoriko Akimoto and Kousuke Hamasu and Eiichiro Onitsuka and Mikako Sato and Yoshihisa Takahata and Fumiki Morimatsu and Mitsuhiro Furuse",

year = "2008",

doi = "10.1271/bbb.80450",

language = "English",

volume = "72",

pages = "3067--3070",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "11",

}

TY - JOUR

T1 - mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

AU - Mizobe, Yurika

AU - Oikawa, Daichi

AU - Tsuyama, Shoichiro

AU - Akimoto, Yoriko

AU - Hamasu, Kousuke

AU - Onitsuka, Eiichiro

AU - Sato, Mikako

AU - Takahata, Yoshihisa

AU - Morimatsu, Fumiki

AU - Furuse, Mitsuhiro

PY - 2008

Y1 - 2008

N2 - Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

AB - Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

UR - http://www.scopus.com/inward/record.url?scp=56749161356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749161356&partnerID=8YFLogxK

U2 - 10.1271/bbb.80450

DO - 10.1271/bbb.80450

M3 - Article

C2 - 18997394

AN - SCOPUS:56749161356

SN - 0916-8451

VL - 72

SP - 3067

EP - 3070

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 11

ER -

mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this