mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

Yurika Mizobe, Daichi Oikawa, Shoichiro Tsuyama, Yoriko Akimoto, Kousuke Hamasu, Eiichiro Onitsuka, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

Original languageEnglish
Pages (from-to)3067-3070
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number11
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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