We previously reported a serum calcium measurement method using Chlorophosphonazo- III (CPZ-III). In this method, the reagent stability is higher than in conventional methods to react samples in an acid medium. High specificity to calcium is also achieved due to the addition of a surfac- tant to the reagent. However, gadolinium, which is used as a contrast agent for magnetic resonance imaging (MRI), causes a positive error in the measurement. Therefore, we have improved our previous method, and developed a new measurement reagent that is not affected by gadolinium. As a result, it was confirmed not to be unaffected by gadolinium to 2.0 mmol/L. Finally, even if our new method is employed just after using a contrast agent, the serum calcium tests should be unaffected. We expect this method to be used as a routine and emergency test in clinical laboratories because it is stable, accurate, and does not contain any heavy metals, dangerous materials, or mutagenic substances.
|Translated title of the contribution||Development of new measurement reagent for serum calcium that avoids influences of gadolinium contrast agent for MRI|
|Journal||Journal of Analytical Bio-Science|
|Publication status||Published - Mar 2010|