Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Michael Platten; Alexandra Kretz; Ulrike Naumann; Steffen Aulwurm; Kensuke Egashira; Stefan Isenmann; Michael Weller

doi:10.1002/ana.10679

Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Michael Platten, Alexandra Kretz, Ulrike Naumann, Steffen Aulwurm, Kensuke Egashira, Stefan Isenmann, Michael Weller

Research output: Contribution to journal › Article › peer-review

203 Citations (Scopus)

Abstract

Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.

Original language	English
Pages (from-to)	388-392
Number of pages	5
Journal	Annals of Neurology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1002/ana.10679
Publication status	Published - Sept 1 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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10.1002/ana.10679

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title = "Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas",

abstract = "Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.",

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AU - Platten, Michael

AU - Kretz, Alexandra

AU - Naumann, Ulrike

AU - Aulwurm, Steffen

AU - Egashira, Kensuke

AU - Isenmann, Stefan

AU - Weller, Michael

PY - 2003/9/1

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N2 - Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.

AB - Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.

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Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Abstract

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