Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Fumiya Mito; Toshihide Yamasaki; Yuko Ito; Mayumi Yamato; Hiroyuki Mino; Hiromi Sadasue; Chisato Shirahama; Kiyoshi Sakai; Hideo Utsumi; Ken Ichi Yamada

doi:10.1039/c0cc05764a

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Fumiya Mito, Toshihide Yamasaki, Yuko Ito, Mayumi Yamato, Hiroyuki Mino, Hiromi Sadasue, Chisato Shirahama, Kiyoshi Sakai, Hideo Utsumi, Ken Ichi Yamada

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer’s disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Original language	English
Pages (from-to)	5070-5072
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	17
DOIs	https://doi.org/10.1039/c0cc05764a
Publication status	Published - May 7 2011

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c0cc05764a

Cite this

@article{b8cdc12cf0b0413dbee191ffd4853d90,

title = "Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical",

abstract = "Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer{\textquoteright}s disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.",

author = "Fumiya Mito and Toshihide Yamasaki and Yuko Ito and Mayumi Yamato and Hiroyuki Mino and Hiromi Sadasue and Chisato Shirahama and Kiyoshi Sakai and Hideo Utsumi and Yamada, {Ken Ichi}",

year = "2011",

month = may,

day = "7",

doi = "10.1039/c0cc05764a",

language = "English",

volume = "47",

pages = "5070--5072",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "17",

}

TY - JOUR

T1 - Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

AU - Mito, Fumiya

AU - Yamasaki, Toshihide

AU - Ito, Yuko

AU - Yamato, Mayumi

AU - Mino, Hiroyuki

AU - Sadasue, Hiromi

AU - Shirahama, Chisato

AU - Sakai, Kiyoshi

AU - Utsumi, Hideo

AU - Yamada, Ken Ichi

PY - 2011/5/7

Y1 - 2011/5/7

N2 - Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer’s disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

AB - Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer’s disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

UR - http://www.scopus.com/inward/record.url?scp=79954436258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954436258&partnerID=8YFLogxK

U2 - 10.1039/c0cc05764a

DO - 10.1039/c0cc05764a

M3 - Article

C2 - 21442105

AN - SCOPUS:79954436258

SN - 1359-7345

VL - 47

SP - 5070

EP - 5072

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this