Molecular structures of mitochondrial-DNA-like sequences in human nuclear DNA

Hisayuki Nomiyama, Makoto Fukuda, Shoji Wakasugi, Teruhisa Tsuzuki, Kazunori Shimada

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Two lambda phage clones carrying mitochondrial-DNA-like (mtDNA-like) sequences isolated from a human gene library were named Lm E-1 and Lm C-2, and their DNA structures were characterized. Lm E-1 contains about 0.4 kb DNA homologous to the 5′ portion of the mitochondria1 16S ribosomal RNA (rRNA) gene and Lm C-2, a 1.6 kb DNA homologous to the 3′ portion of the 12S rRNA gene and to almost all of the 16S rRNA gene. Comparisons of their nucleotide sequences with those of the corresponding regions of the human mtDNA revealed no detectable DNA rearrangement and their homologies to the human mtDNA are 84% and 80%, respectively. There are neither terminal repeats in the nuclear mtDNA-like sequences nor duplications of the nuclear DNAs flanking the mtDNA-like sequences. Evolutionary relationship between these two human nuclear mtDNA-like sequences and the human and bovine mtDNAs is discussed.

Original languageEnglish
Pages (from-to)1649-1658
Number of pages10
JournalNucleic acids research
Issue number5
Publication statusPublished - Mar 11 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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