TY - JOUR
T1 - Molecular Pathways Governing Development of Vascular Endothelial Cells from ES/iPS Cells
AU - Tan, Keai Sinn
AU - Tamura, Kiyomi
AU - Lai, Mei I.
AU - Veerakumarasivam, Abhimanyu
AU - Nakanishi, Yoichi
AU - Ogawa, Minetaro
AU - Sugiyama, Daisuke
N1 - Funding Information:
Acknowledgments We thank Drs. Kenzaburo Tani and Koichi Akashi and Sugiyama lab members for discussion, Dr. Elise Lamar for editing the manuscript, and the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, the Japan Society for the Promotion of Science, the Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical care, and Institute of Molecular Embryology and Genetics for grant support. Keai Sinn Tan is a recipient of scholarship from The Tokyo Biochemical Research Foundation, Japan and MyPhD scholarship from Ministry of Higher Education (MOHE), Malaysia.
PY - 2013/10
Y1 - 2013/10
N2 - Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type, including endothelial cells (ECs), and have been extensively used as in vitro models to analyze molecular mechanisms underlying EC generation and differentiation. The emergence of these promising new approaches suggests that ECs could be used in clinical therapy. Much evidence suggests that ES/iPS cell differentiation into ECs in vitro mimics the in vivo vascular morphogenic process. Through sequential steps of maturation, ECs derived from ES/iPS cells can be further differentiated into arterial, venous, capillary and lymphatic ECs, as well as smooth muscle cells. Here, we review EC development from ES/iPS cells with special attention to molecular pathways functioning in EC specification.
AB - Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type, including endothelial cells (ECs), and have been extensively used as in vitro models to analyze molecular mechanisms underlying EC generation and differentiation. The emergence of these promising new approaches suggests that ECs could be used in clinical therapy. Much evidence suggests that ES/iPS cell differentiation into ECs in vitro mimics the in vivo vascular morphogenic process. Through sequential steps of maturation, ECs derived from ES/iPS cells can be further differentiated into arterial, venous, capillary and lymphatic ECs, as well as smooth muscle cells. Here, we review EC development from ES/iPS cells with special attention to molecular pathways functioning in EC specification.
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U2 - 10.1007/s12015-013-9450-7
DO - 10.1007/s12015-013-9450-7
M3 - Article
C2 - 23765563
AN - SCOPUS:84884812307
SN - 1550-8943
VL - 9
SP - 586
EP - 598
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
IS - 5
ER -
