TY - JOUR
T1 - Molecular-length and chiral discriminations by β-structural poly(L-alanine) on silica
AU - Shundo, Atsuomi
AU - Sakurai, Toshihiko
AU - Takafuji, Makoto
AU - Nagaoka, Shoji
AU - Ihara, Hirotaka
N1 - Funding Information:
This research was supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2005/5/6
Y1 - 2005/5/6
N2 - Poly(l-alanine)-grafted porous silica (Sil-Ala22) was prepared by polymerization of N-carboxyanhydride of l-alanine initiated by 3-aminopropylated silica. Its selective interaction with aromatic guest molecules was evaluated by the retention time in liquid chromatography using the column packed with Sil-Ala22. Sil-Ala22 showed a specific selective retention with discriminating molecular shapes, such as molecular length, linearity and planarity. This selectivity can be explained by a multiple π-π interaction with the carbonyl groups one dimensionally-aligned on the rigid β-form structure in the peptide main chain. Chiral separation with Sil-Ala22 was also described.
AB - Poly(l-alanine)-grafted porous silica (Sil-Ala22) was prepared by polymerization of N-carboxyanhydride of l-alanine initiated by 3-aminopropylated silica. Its selective interaction with aromatic guest molecules was evaluated by the retention time in liquid chromatography using the column packed with Sil-Ala22. Sil-Ala22 showed a specific selective retention with discriminating molecular shapes, such as molecular length, linearity and planarity. This selectivity can be explained by a multiple π-π interaction with the carbonyl groups one dimensionally-aligned on the rigid β-form structure in the peptide main chain. Chiral separation with Sil-Ala22 was also described.
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U2 - 10.1016/j.chroma.2004.08.062
DO - 10.1016/j.chroma.2004.08.062
M3 - Article
C2 - 15909519
AN - SCOPUS:17444420383
SN - 0021-9673
VL - 1073
SP - 169
EP - 174
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1-2
ER -