'Molecular-imprinting' in polyion complexes which creates the 'memory' for the AMP template

Yasumasa Kanekiyo, Yoshiyuki Ono, Kazuhiko Inoue, Masahito Sano, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


The formation of a polyion complex precipitate was applied to molecular imprinting for the first time. Polyanion containing boronic acid units can sustain AMP by a boronate-cis-diol interaction. When this polyanion forms a polyion complex with polycation according to 1 : 1 cation-anion stoichiometry, the phosphate anionic charges introduced into the polyanion by the AMP complexation are also counted. Thus, after removal of AMP from the polyion complex a 'cleft' which has the memory for the AMP template is created. It was proved that this cleft shows high affinity with AMP. We also noticed that the removal and re-binding processes for AMP coincide with the swelling and deswelling phenomena of this polyion complex.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalJournal of the Chemical Society. Perkin Transactions 2
Issue number3
Publication statusPublished - Mar 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


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