TY - JOUR
T1 - Molecular design of synthetic receptors with dynamic, imprinting, and allosteric functions
AU - Shinkai, Seiji
AU - Takeuchi, Masayuki
PY - 2005/1
Y1 - 2005/1
N2 - Sugar recognition in an aqueous system has been achieved using a boronic acid-diol interaction. Combination with an intramolecular amino group has enabled us to read out the binding process as a change in the fluorescence intensity. This novel sugar-sensing method has been combined with a concept of "molecular machinery", providing a new guest-binding mode with allosteric functions. When this method is combined with a concept of "molecular imprinting", it becomes possible to design sugar-selective receptors created by a combinatorial method. The sugar recognition event is useful as a trigger to control molecular assemblies such as micelles, membranes, vesicles, and gels.
AB - Sugar recognition in an aqueous system has been achieved using a boronic acid-diol interaction. Combination with an intramolecular amino group has enabled us to read out the binding process as a change in the fluorescence intensity. This novel sugar-sensing method has been combined with a concept of "molecular machinery", providing a new guest-binding mode with allosteric functions. When this method is combined with a concept of "molecular imprinting", it becomes possible to design sugar-selective receptors created by a combinatorial method. The sugar recognition event is useful as a trigger to control molecular assemblies such as micelles, membranes, vesicles, and gels.
UR - http://www.scopus.com/inward/record.url?scp=13444291195&partnerID=8YFLogxK
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U2 - 10.1246/bcsj.78.40
DO - 10.1246/bcsj.78.40
M3 - Article
AN - SCOPUS:13444291195
SN - 0009-2673
VL - 78
SP - 40
EP - 51
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 1
ER -