Molecular design of calixarene-based ion-selective electrodes

Toru Sakaki, Takaaki Harada, Gang Deng, Hirosuke Kawabata, Yohko Kawahara, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


In order to obtain insights into relationships between the calix[4]arene structure and the ion selectivity in the electrode system, 20 ionophoric calix[4]arenes were synthesized and their ion selectivity (with Na+ as a standard) estimated. Among these ionophoric calix[4]arenes, 25,26,27,28-tetrakis[(ethoxycarbonyl)methoxy]-p-t-octylcalix[4]arene afforded the highest log KNA,Mpot value (-3.1) in the presence of 2-fluorophenyl-2′-nitrophenylether (10) as the best of 13 plasticizers. This is the first example in which the Na+/K+ selectivity exceeds a factor of 103 in the electrode system based on the neutral carrier. The high Na+ selectivity is attributed to modification of the upper rim which ostensibly has no relation with the component of the cavity. This paper demonstrates the potential relationships between the unique structure of the calix[4]arene-based ligands and selectivity performance for the design of ion-selective electrodes.

Original languageEnglish
Pages (from-to)285-302
Number of pages18
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Issue number3-4
Publication statusPublished - Sept 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Food Science
  • General Chemistry
  • Condensed Matter Physics


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