Molecular basis for pre-TCR-mediated autonomous signaling

Sho Yamasaki, Takashi Saito

Research output: Contribution to journalReview articlepeer-review

54 Citations (Scopus)

Abstract

The pre-T-cell receptor (pre-TCR) is a multimeric complex composed of a nascent TCRβ chain, an invariant pre-TCRα (pTα) chain and CD3 molecules, and is crucial for early T-cell development. Despite its structural similarity to the mature αβTCR, which requires MHC-antigen for receptor triggering, the pre-TCR is proposed to initiate signals in a ligand-independent manner. However, the molecular mechanism underlying the autonomous signaling is still unclear. Recent studies have revealed that pTα possesses unique characteristics that promote autonomous signaling. In this review, we summarize current data relating to the molecular mechanism underlying the initiation of pre-TCR-mediated autonomous signaling.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalTrends in Immunology
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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