Molecular and Neuronal Mechanisms of Forgetting

Miari Arai, Takeshi Ishihara

Research output: Contribution to journalReview articlepeer-review


Animals sense several types of information in their environments and some of those information are stored as memories. The retention of these memories must be regulated for the animals to survive continuously changing environments. However, the mechanisms underlying memory forgetting remain to be understood, partly because psychological studies have suggested that forgetting is a passive process. Recent behavioral genetic studies, using model animals, including mice, Drosophila and Caenorhabditis elegans, have revealed that forgetting is actively regulated in neuronal circuits. In particular, "forgetting cells" non-cell-autonomously accelerate forgetting in other neurons. In this review, we describe recent studies of the mechanisms of forgetting in model animals.

Original languageEnglish
Pages (from-to)689-697
Number of pages9
JournalBrain and nerve = Shinkei kenkyu no shinpo
Issue number7
Publication statusPublished - Jul 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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