Modulation of taste responsiveness by angiotensin II

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3 Citations (Scopus)


Angiotensin II and aldosterone are key hormones regulating sodium and water balance. Investigations of the taste system in rat have shown that the amiloride-sensitivity of the taste nerve responses to NaCl is enhanced by aldosterone treatment over a time course of several hours. A recent study further revealed that angiotensin II suppresses the amiloride-sensitivity of the mouse gustatory NaCl responses and enhances sweet taste sensitivity within one hour, without affecting umami, sour and bitter responses. These results suggest the presence of a reciprocal regulatory mechanism of salty taste sensitivity by angiotensin II as an acute suppressor and aldosterone as a slow enhancer in peripheral taste organs, which may play an important role in maintaining sodium homeostasis. Moreover, the possible cross-talk between salty and sweet taste modulation by angiotensin II signaling may optimize sodium and calorie intake.

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalFood Science and Technology Research
Issue number6
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing


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