Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors

Masafumi Jyotaki, Noriatsu Shigemura, Yuzo Ninomiya

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)


The present study summarized recent findings on roles of leptin and endocannabinoids as modulators of the peripheral components of sweet taste. The positive effect of endocannabinoids on sweet sensitivity was opposed to that of leptin which suppresses sweet sensitivity. Leptin and endocannabinoids, therefore, not only regulate food intake via central nervous systems but also may modulate palatability of foods by altering peripheral sweet taste responses via their cognate receptors. Orexigenic and anorexigenic factors such as endocannnabinoids and leptin may affect energy homeostasis by regulating taste sensitivity.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalEndocrine Journal
Issue number6
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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