TY - GEN
T1 - Modulation of intracortical inhibition and facilitation of motor cortex through transcranial direct current stimulation
AU - Ogata, Katsuya
AU - Yamasaki, Takao
AU - Tobimatsu, Shozo
PY - 2007
Y1 - 2007
N2 - Transcranial direct current stimulation (tDCS) can modulate cortical function transiently. This effect is monitored by motor evoked potentials (MEPs). The excitability of intracortical circuits in the motor cortex is assessed by paired pulse stimulation. In previous MEP studies, the modulation of short latency intracortical inhibition (SICI) and intracortical facilitation (ICF) with tDCS was demonstrated. In order to elucidate the neural mechanisms of tDCS, we evaluated the long latency intracortical inhibition (LICI) and short latency afferent inhibition (SAI) as well as SICI and ICF as objective parameters. There was a siginificant modulation of MEP amplitudes of single pulse TMS, however, SICI, ICF, LICI, and SAI were not significantly altered. Our results suggest that tDCS does not modulate neurotransmitter related to each parameter. Therefore, the modulation of MEP amplitudes of single pulse TMS may result from the change of membrane potentials.
AB - Transcranial direct current stimulation (tDCS) can modulate cortical function transiently. This effect is monitored by motor evoked potentials (MEPs). The excitability of intracortical circuits in the motor cortex is assessed by paired pulse stimulation. In previous MEP studies, the modulation of short latency intracortical inhibition (SICI) and intracortical facilitation (ICF) with tDCS was demonstrated. In order to elucidate the neural mechanisms of tDCS, we evaluated the long latency intracortical inhibition (LICI) and short latency afferent inhibition (SAI) as well as SICI and ICF as objective parameters. There was a siginificant modulation of MEP amplitudes of single pulse TMS, however, SICI, ICF, LICI, and SAI were not significantly altered. Our results suggest that tDCS does not modulate neurotransmitter related to each parameter. Therefore, the modulation of MEP amplitudes of single pulse TMS may result from the change of membrane potentials.
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U2 - 10.1109/ICCME.2007.4382099
DO - 10.1109/ICCME.2007.4382099
M3 - Conference contribution
AN - SCOPUS:48149107838
SN - 1424410789
SN - 9781424410781
T3 - 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
SP - 2000
EP - 2003
BT - 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
T2 - 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
Y2 - 23 May 2007 through 27 May 2007
ER -