Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro

H. Kusumoto; Y. Maehara; Y. Sakaguchi; S. Kohnoe; R. Kumashiro; K. Sugimachi

Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro

H. Kusumoto, Y. Maehara, Y. Sakaguchi, S. Kohnoe, R. Kumashiro, K. Sugimachi

Research output: Contribution to journal › Article › peer-review

Abstract

Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyladriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.

Original language	English
Pages (from-to)	1643-1645
Number of pages	3
Journal	Anticancer research
Volume	10
Issue number	6
Publication status	Published - 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro",

abstract = "Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyladriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.",

author = "H. Kusumoto and Y. Maehara and Y. Sakaguchi and S. Kohnoe and R. Kumashiro and K. Sugimachi",

year = "1990",

language = "English",

volume = "10",

pages = "1643--1645",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6",

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TY - JOUR

T1 - Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro

AU - Kusumoto, H.

AU - Maehara, Y.

AU - Sakaguchi, Y.

AU - Kohnoe, S.

AU - Kumashiro, R.

AU - Sugimachi, K.

PY - 1990

Y1 - 1990

N2 - Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyladriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.

AB - Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyladriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.

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M3 - Article

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AN - SCOPUS:0025681272

SN - 0250-7005

VL - 10

SP - 1643

EP - 1645

JO - Anticancer research

JF - Anticancer research

IS - 6

ER -

Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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