TY - JOUR
T1 - Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglyceriwdes by ALDH2 and ADH1B polymorphisms in Japanese men
AU - Sasakabe, Tae
AU - Wakai, Kenji
AU - Kawai, Sayo
AU - Hishida, Asahi
AU - Naito, Mariko
AU - Suzuki, Sadao
AU - Nindita, Yora
AU - Arisawa, Kokichi
AU - Kita, Yoshikuni
AU - Hara, Megumi
AU - Kuriyama, Nagato
AU - Hirata, Akie
AU - Mikami, Haruo
AU - Oze, Isao
AU - Kubo, Michiaki
AU - Tanaka, Hideo
AU - Hamajima, Nobuyuki
N1 - Funding Information:
(Nos. 16H06277 and 15H02524) and Grants-in-Aid for Scientific Research on Priority Areas (No. 17015018) and Innovative Areas (No. 221S0001) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology. Conflicts of interest: None declared.
Funding Information:
We thank Kyota Ashikawa, Tomomi Aoi, and the other members of the Laboratory for Genotyping Development, RIKEN Center for Genomic Medicine, for their support with the genotyping in the study, as well as Yoko Mitsuda, Keiko Shibata, and Etsuko Kimura of the Department of Preventive Medicine, Nagoya University Graduate School of Medicine, for their technical assistance. We also thank Shinkan Tokudome of the National Institute of Health and Nutrition (formerly Nagoya City University), Chiho Goto of Nagoya Bunri University, Nahomi Imaeda of Shigakkan University, Yuko Tokudome of the Nagoya University of Arts and Science, Masato Ikeda of the University of Occupational and Environmental Health, and Shinzo Maki of the Aichi Prefectural Dietetic Association for providing the food frequency questionnaire and a program for calculating the participants’ nutritional intake. We thank all of the members of the Seirei Social Welfare Community for the recruitment and follow-up of participants in the Shizuoka part of the J-MICC study. This study was supported by JSPS KAKENHI Grants
Publisher Copyright:
© 2017 Tae Sasakabe et al.
PY - 2018
Y1 - 2018
N2 - Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu=Lys or Lys=Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g=day was −2.49 mg=dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His=His + ALDH2 Glu=Lys or Lys=Lys groups (−3.24 mg=dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His=His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu=Lys or Lys=Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.
AB - Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu=Lys or Lys=Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g=day was −2.49 mg=dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His=His + ALDH2 Glu=Lys or Lys=Lys groups (−3.24 mg=dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His=His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu=Lys or Lys=Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.
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U2 - 10.2188/jea.JE20160189
DO - 10.2188/jea.JE20160189
M3 - Article
C2 - 29176272
AN - SCOPUS:85047743295
SN - 0917-5040
VL - 28
SP - 185
EP - 193
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - 4
ER -