Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity

Hironobu Takahashi, Yasuro Niidome, Takuro Niidome, Kenji Kaneko, Hideya Kawasaki, Sunao Yamada

    Research output: Contribution to journalArticlepeer-review

    400 Citations (Scopus)


    Hexadecyltrimethylammonium bromide (CTAB), which is necessary for the preparation of gold nanorods (NRs), was extracted from a NR solution into a chloroform phase containing phosphatidylcholine (PC). After three extractions, the zeta potential of the NRs remained positive, but its magnitude decreased from+67 ±1 to+15± 1 mV. Transmission electron microscopy and energy-dispersive X-ray analysis indicated that the NRs were passivated with PC. The PC layer on the NR surface contributed to the prevention of NR aggregation. The PC-passivated NRs showed low cytotoxicity in comparison with twice-centrifuged NRs. It was shown that a negligible amount of CTAB was dispersed in the NR solution after the extraction. The extraction using a chloroform phase containing PC was found to be a convenient way of replacing the CTAB with alternative capping agents such as PC. This is a key technique for preparing functional NRs that can have practical applications.

    Original languageEnglish
    Pages (from-to)2-5
    Number of pages4
    Issue number1
    Publication statusPublished - Jan 3 2006

    All Science Journal Classification (ASJC) codes

    • General Materials Science
    • Condensed Matter Physics
    • Surfaces and Interfaces
    • Spectroscopy
    • Electrochemistry


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