Mobilization of human lymphoid progenitors after treatment with granulocyte colony-stimulating factor

Rie Imamura, Toshihiro Miyamoto, Goichi Yoshimoto, Kenjiro Kamezaki, Fumihiko Ishikawa, Hideho Henzan, Koji Kato, Ken Takase, Akihiko Numata, Koji Nagafuji, Takashi Okamura, Michio Sata, Mine Harada, Shoichi Inaba

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27 Citations (Scopus)


Hemopoietic stem and progenitor cells ordinarily residing within bone marrow are released into the circulation following G-CSF administration. Such mobilization has a great clinical impact on hemopoietic stem cell transplantation. Underlying mechanisms are incompletely understood, but may involve G-CSF-induced modulation of chemokines, adhesion molecules, and proteolytic enzymes. We studied G-CSF-induced mobilization of CD34 +CD10+CD19-Lin- and CD34 +CD10+CD19+Lin- cells (early B and pro-B cells, respectively). These mobilized lymphoid populations could differentiate only into B/NK cells or B cells equivalent to their marrow counterparts. Mobilized lymphoid progenitors expressed lymphoid- but not myeloid-related genes including the G-CSF receptor gene, and displayed the same pattern of Ig rearrangement status as their bone marrow counterparts. Decreased expression of VLA-4 and CXCR-4 on mobilized lymphoid progenitors as well as multipotent and myeloid progenitors indicated lineage-independent involvement of these molecules in G-CSF-induced mobilization. The results suggest that by acting through multiple trans-acting signals, G-CSF can mobilize not only myeloid-committed populations but a variety of resident marrow cell populations including lymphoid progenitors.

Original languageEnglish
Pages (from-to)2647-2654
Number of pages8
JournalJournal of Immunology
Issue number4
Publication statusPublished - Aug 15 2005

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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