Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus: a case report

Shotaro Korehisa, Hiroshi Saeki, Yuichiro Nakashima, Yu Nakaji, Satoshi Tsutsumi, Takafumi Yukaya, Hirotada Tajiri, Yuta Kasagi, Hideto Sonoda, Masahiko Sugiyama, Kippei Ohgaki, Eiji Oki, Minako Hirahashi, Hidetaka Yamamoto, Yoshihiko Maehara

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Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
Issue number3
Publication statusPublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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