Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model

Hideyuki Fumoto; Tohru Takaseya; Akira Shiose; Roberto M. Saraiva; Yoko Arakawa; Margaret Park; Santosh Rao; Raymond Dessoffy; Ji Feng Chen; Qun Zhou; Anthony Calabro; Michael Banbury; Kiyotaka Fukamachi

doi:10.1532/HSF98.20101003

Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model

Hideyuki Fumoto, Tohru Takaseya, Akira Shiose, Roberto M. Saraiva, Yoko Arakawa, Margaret Park, Santosh Rao, Raymond Dessoffy, Ji Feng Chen, Qun Zhou, Anthony Calabro, Michael Banbury, Kiyotaka Fukamachi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

Original language	English
Pages (from-to)	E247-E250
Journal	Heart Surgery Forum
Volume	13
Issue number	4
DOIs	https://doi.org/10.1532/HSF98.20101003
Publication status	Published - Aug 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Surgery
Cardiology and Cardiovascular Medicine

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@article{43382b7888ea44aca7ab6a98a87b64a5,

title = "Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model",

abstract = "Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.",

author = "Hideyuki Fumoto and Tohru Takaseya and Akira Shiose and Saraiva, {Roberto M.} and Yoko Arakawa and Margaret Park and Santosh Rao and Raymond Dessoffy and Chen, {Ji Feng} and Qun Zhou and Anthony Calabro and Michael Banbury and Kiyotaka Fukamachi",

year = "2010",

month = aug,

doi = "10.1532/HSF98.20101003",

language = "English",

volume = "13",

pages = "E247--E250",

journal = "Heart Surgery Forum",

issn = "1098-3511",

publisher = "Carden Jennings Publishing Co. Ltd",

number = "4",

}

TY - JOUR

T1 - Mitral annular remodeling to treat functional mitral regurgitation

T2 - A pilot acute study in a canine model

AU - Fumoto, Hideyuki

AU - Takaseya, Tohru

AU - Shiose, Akira

AU - Saraiva, Roberto M.

AU - Arakawa, Yoko

AU - Park, Margaret

AU - Rao, Santosh

AU - Dessoffy, Raymond

AU - Chen, Ji Feng

AU - Zhou, Qun

AU - Calabro, Anthony

AU - Banbury, Michael

AU - Fukamachi, Kiyotaka

PY - 2010/8

Y1 - 2010/8

N2 - Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

AB - Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

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ER -

Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model

Abstract

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