Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.

Original languageEnglish
Pages (from-to)3629-3632
Number of pages4
JournalChemical Communications
Volume58
Issue number22
DOIs
Publication statusPublished - Feb 24 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model'. Together they form a unique fingerprint.

Cite this