Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Guan Wu, Yi Rao, Jane Y. Wu

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

Original languageEnglish
Pages (from-to)1087-1089
Number of pages3
JournalNature Neuroscience
Issue number9
Publication statusPublished - Sept 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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