Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada; Mariko Kinoshita-Kawada; Guan Wu; Yi Rao; Jane Y. Wu

doi:10.1038/nn.2382

Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Guan Wu, Yi Rao, Jane Y. Wu

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

Original language	English
Pages (from-to)	1087-1089
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	9
DOIs	https://doi.org/10.1038/nn.2382
Publication status	Published - Sept 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1038/nn.2382

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title = "Midline crossing and Slit responsiveness of commissural axons require USP33",

abstract = "Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.",

author = "Junichi Yuasa-Kawada and Mariko Kinoshita-Kawada and Guan Wu and Yi Rao and Wu, {Jane Y.}",

note = "Funding Information: We thank Y. Zou and F. Murakami for generously providing the Sema3F construct and the antibody to Robo1, respectively, M. Katakura for support during this work and X. Chen for excellent technical support. This work has been supported by the James S. McDonnell Foundation (grant JSMF 220020180 to J.Y.W.) and the US National Institutes of Health (grants CA114197 and CA107193 to J.Y.W.).",

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doi = "10.1038/nn.2382",

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AU - Yuasa-Kawada, Junichi

AU - Kinoshita-Kawada, Mariko

AU - Wu, Guan

AU - Rao, Yi

AU - Wu, Jane Y.

N1 - Funding Information: We thank Y. Zou and F. Murakami for generously providing the Sema3F construct and the antibody to Robo1, respectively, M. Katakura for support during this work and X. Chen for excellent technical support. This work has been supported by the James S. McDonnell Foundation (grant JSMF 220020180 to J.Y.W.) and the US National Institutes of Health (grants CA114197 and CA107193 to J.Y.W.).

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N2 - Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

AB - Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

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Midline crossing and Slit responsiveness of commissural axons require USP33

Abstract

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