Microtubules in non-conventional yeasts

Research output: Chapter in Book/Report/Conference proceedingChapter


Microtubules polymerise from tubulin proteins and play a significant role in the growth and proliferation of eukaryotic cells. In yeasts, most studies on microtubules and tubulins have utilised the budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe model systems. However, more recently interest in the microtubules of other non-conventional yeast and fungal species has increased, both for investigation of biological processes such as fungal evolution and for applications such as developing antifungal drugs. We review the microtubule cytoskeleton and its role in yeast and fungal cellular processes in vivo and the tubulin proteins found in yeast cells and their study in vitro, together with the recent advances in cryoEM leading to detailed molecular structures of yeast microtubules. We examine what is known about the microtubule cytoskeleton in non-conventional yeasts and highlight the significant differences, as well as many conserved aspects, in their microtubule biology compared to the two model yeasts. Finally, we discuss the potential role of microtubules as drug targets for treatment of yeast and fungal infections.

Original languageEnglish
Title of host publicationNon-conventional Yeasts
Subtitle of host publicationfrom Basic Research to Application
PublisherSpringer International Publishing
Number of pages60
ISBN (Electronic)9783030211103
ISBN (Print)9783030211100
Publication statusPublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine(all)


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