TY - JOUR
T1 - microRNA-based cancer cell reprogramming technology (review)
AU - Nishikawa, Shimpei
AU - Ishii, Hideshi
AU - Haraguchi, Naotsugu
AU - Kano, Yoshihiro
AU - Fukusumi, Takahito
AU - Ohta, Katsuya
AU - Ozaki, Miyuki
AU - Dewi, Dyah Laksmi
AU - Sakai, Daisuke
AU - Satoh, Taroh
AU - Nagano, Hiroaki
AU - Doki, Yuichiro
AU - Mori, Masaki
PY - 2012/7
Y1 - 2012/7
N2 - Epigenetic modifications play crucial roles in cancer initiation and development. Complete reprogramming can be achieved through the introduction of defined biological factors such as Oct4, Sox2, Klf4, and cMyc into mouse and human fibroblasts. Introduction of these transcription factors resulted in the modification of malignant phenotype behavior. Recent studies have shown that human and mouse somatic cells can be reprogrammed to become induced pluripotent stem cells using forced expression of microRNAs, which completely eliminates the need for ectopic protein expression. Considering the usefulness of RNA molecules, microRNA-based reprogramming technology may have future applications in regenerative and cancer medicine.
AB - Epigenetic modifications play crucial roles in cancer initiation and development. Complete reprogramming can be achieved through the introduction of defined biological factors such as Oct4, Sox2, Klf4, and cMyc into mouse and human fibroblasts. Introduction of these transcription factors resulted in the modification of malignant phenotype behavior. Recent studies have shown that human and mouse somatic cells can be reprogrammed to become induced pluripotent stem cells using forced expression of microRNAs, which completely eliminates the need for ectopic protein expression. Considering the usefulness of RNA molecules, microRNA-based reprogramming technology may have future applications in regenerative and cancer medicine.
UR - http://www.scopus.com/inward/record.url?scp=84865778514&partnerID=8YFLogxK
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U2 - 10.3892/etm.2012.558
DO - 10.3892/etm.2012.558
M3 - Article
AN - SCOPUS:84865778514
SN - 1792-0981
VL - 4
SP - 8
EP - 14
JO - Experimental and Therapeutic Medicine
JF - Experimental and Therapeutic Medicine
IS - 1
ER -
