Microfluidic single-particle chemical analyzer with dual-comb coherent Raman spectroscopy

Takuro Ideguchi, Tasuku Nakamura, Shigekazu Takizawa, Miu Tamamitsu, Sangwook Lee, Kotaro Hiramatsu, Venkata Ramaiah-Badarla, Jee Woong Park, Yusuke Kasai, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai, Keisuke Goda

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Label-free particle analysis is a powerful tool in chemical, pharmaceutical, and cosmetic industries as well as in basic sciences, but its throughput is significantly lower than that of fluorescence-based counterparts. Here we present a labelfree single-particle analyzer based on broadband dual-comb coherent Raman scattering spectroscopy operating at a spectroscopic scan rate of 10 kHz. As a proof-of-concept demonstration, we perform broadband coherent anti-Stokes Raman scattering measurements of polystyrene microparticles flowing on an acoustofluidic chip at a high throughput of >1000 particles per second. This high-throughput labelfree particle analyzer has the potential for high-precision statistical analysis of a large number of microparticles including biological cells.

Original languageEnglish
Pages (from-to)4057-4060
Number of pages4
JournalOptics Letters
Issue number16
Publication statusPublished - Aug 15 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics


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