TY - GEN
T1 - Microfluidic external gelation of shape-controlled calcium-alginate hydrogels for drug encapsulation and sustained release
AU - Liu, Yingzhe
AU - Tottori, Naotomo
AU - Nisisako, Takasi
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We report microfluidic in-situ external gelation for preparing calcium(Ca)-alginate hydrogels of precisely defined shapes for controlled drug release. We demonstrated that homogeneous spatial distribution of reactant CaCl2emulsions around precursor sodium(Na)-alginate droplets is essential to obtain highly spherical hydrogels. UV-Vis measurement was performed to demonstrate sustained release of encapsulated anti-fouling drug Irgarol. Magneto-responsive Janus gels and hemi-spherical gels made from Na-alginate/Grycerol Janus droplets are also presented.
AB - We report microfluidic in-situ external gelation for preparing calcium(Ca)-alginate hydrogels of precisely defined shapes for controlled drug release. We demonstrated that homogeneous spatial distribution of reactant CaCl2emulsions around precursor sodium(Na)-alginate droplets is essential to obtain highly spherical hydrogels. UV-Vis measurement was performed to demonstrate sustained release of encapsulated anti-fouling drug Irgarol. Magneto-responsive Janus gels and hemi-spherical gels made from Na-alginate/Grycerol Janus droplets are also presented.
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M3 - Conference contribution
T3 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
SP - 2183
EP - 2184
BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PB - Chemical and Biological Microsystems Society
T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Y2 - 11 November 2018 through 15 November 2018
ER -