Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant

H. Nishimura; M. Tagaya; H. Tsunobuchi; H. Suzuki; I. Nakashima; Y. Yoshikai

doi:10.1128/IAI.69.2.1226-1229.2001

Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant

H. Nishimura, M. Tagaya, H. Tsunobuchi, H. Suzuki, I. Nakashima, Y. Yoshikai

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)^-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2^-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2^-/- but not in IL-2/IL-15Rβ^-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.

Original language	English
Pages (from-to)	1226-1229
Number of pages	4
Journal	Infection and Immunity
Volume	69
Issue number	2
DOIs	https://doi.org/10.1128/IAI.69.2.1226-1229.2001
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/IAI.69.2.1226-1229.2001

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Nishimura, H., Tagaya, M., Tsunobuchi, H., Suzuki, H., Nakashima, I., & Yoshikai, Y. (2001). Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant. Infection and Immunity, 69(2), 1226-1229. https://doi.org/10.1128/IAI.69.2.1226-1229.2001

Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant. / Nishimura, H.; Tagaya, M.; Tsunobuchi, H. et al.
In: Infection and Immunity, Vol. 69, No. 2, 2001, p. 1226-1229.

Research output: Contribution to journal › Article › peer-review

Nishimura, H, Tagaya, M, Tsunobuchi, H, Suzuki, H, Nakashima, I & Yoshikai, Y 2001, 'Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant', Infection and Immunity, vol. 69, no. 2, pp. 1226-1229. https://doi.org/10.1128/IAI.69.2.1226-1229.2001

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abstract = "Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.",

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AU - Tsunobuchi, H.

AU - Suzuki, H.

AU - Nakashima, I.

AU - Yoshikai, Y.

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Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant

Abstract

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